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3D
COMSOL Modeling of Temperature Gradient Focusing via Joule
Heating in Micro Fluidic Channels
Speaker: Ge Zhengwei (P.H.D), Nanyang Technological
University
Temperature gradient focusing (TGF) is a recently developed
technique for spatially focusing and separating ionic
analytes in microchannels, by balancing the bulk flow
against electrophoretic migrating flux of the analytes along
a controlled temperature profile. The temperature gradient
required for TGF can be generated by Joule heating resulting
from an applied DC electric field. In this study, a
comprehensive 3D numerical model describing the Joule
heating induced temperature development and TGF is developed
in COMSOL. The model consists of the Laplace equation for
applied electric field, the incompressible Navier–Stokes
equations for the fluid flow, the energy equations for
temperature field distribution and the mass transport
equation for the concentration of sample solute. As the
thermophysical and electrical properties including the
liquid dielectric constant, viscosity, and electric
conductivity and electrophoretic mobility are
temperature-dependent, these governing equations are coupled
and solved numerically to predict the resulting temperature,
velocity and concentration profiles. The model is used to
analyze the effects of varying certain geometrical and
experimental paramenters on the focusing performance of the
device, such as channel width and electric potential.
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